Astragalus Root Extract, a traditional herb in Chinese medicine, has recently gained attention in the realms of bodybuilding, anti-aging, and Human Growth Hormone (HGH) enhancement.

This natural supplement, derived from the roots of the Astragalus plant, is believed to have multiple health benefits, including the potential to naturally stimulate HGH production.

Understanding how Astragalus Root Extract influences HGH levels can offer valuable insights for those seeking natural methods to boost their physical performance, slow aging, and improve overall vitality.

This comprehensive review delves into the scientific evidence surrounding Astragalus Root Extract and its impact on HGH, exploring its mechanisms and potential benefits in a fitness and wellness context.

Astragalus Root Extract and Human Growth Hormone (HGH) Enhancement


Expression in Chondrocytes

Astragalus Root Extract has been shown to play a significant role in the expression of recombinant human growth hormone in chondrocytes.

Kim et al. (2010) highlighted this effect, demonstrating that the extract can enhance growth hormone levels in these cells. [1]

Chondrocytes are integral in cartilage formation and growth, suggesting that Astragalus Root Extract could contribute to improved joint health and overall growth hormone activity, which is crucial for bodybuilders and athletes.

Telomerase Activity

Another fascinating aspect of Astragalus Root Extract is its impact on telomerase activity. The TA-65 extract, derived from Astragalus, significantly increases telomerase activity in human T cells, as observed by Molgora et al. (2013). [2]

Telomerase is an enzyme that helps maintain the length of telomeres, which are protective caps on the ends of chromosomes.

This maintenance is essential for cellular health and longevity.

The increase in telomerase activity suggests a potential effect on growth hormone levels, as well as implications for anti-aging and overall cellular health.

This could be particularly beneficial for those focused on anti-aging, as maintaining telomere length is associated with youthfulness and longevity.

Upregulation of IGF-1

A key mechanism through which Astragalus Root Extract enhances HGH is by stimulating bone growth rate.

Lee et al. (2017) discovered that it upregulates liver IGF-1 (Insulin-like Growth Factor 1) and IGFBP-3 (Insulin-like Growth Factor Binding Protein 3) mRNA. [3]

This upregulation directly stimulates growth hormone, crucial for bone health and development.

For bodybuilders and athletes, this means enhanced bone strength and potentially improved performance due to the critical role of IGF-1 in muscle growth and repair.

Promotion of Growth Hormone Secretion

Further research by Lee et al. (2021) highlights Astragalus Root Extract’s ability to enhance growth hormone secretion. [4]

This enhancement is not just limited to a direct stimulatory effect; it also involves the neuroendocrine regulatory system, indicating a more holistic impact on the body’s hormonal balance.

The increase in bone formation in cartilage is particularly beneficial for athletes and bodybuilders, as it supports skeletal health, which is fundamental for physical training and performance.

Implications for Bodybuilding and Anti-Aging regarding Astragalus use as a HGH boosting supplement

  • Enhanced Muscle Growth and Recovery: The upregulation of IGF-1 and promotion of growth hormone secretion contribute to muscle growth and recovery, essential for bodybuilders.
  • Improved Bone Density and Strength: The positive impact on bone health can lead to improved bone density and strength, reducing the risk of injuries and supporting heavier and more intense workouts.
  • Regulation of Metabolic Functions: IGF-1 plays a vital role in regulating metabolic functions, which is crucial for maintaining an optimal body composition.
  • Support in Anti-Aging: The holistic impact on the neuroendocrine system and the enhancement of growth hormone secretion can contribute to anti-aging effects, maintaining vitality and reducing the signs of aging.

Astragalus Root Extract’s Benefits in Anti-Aging

Astragalus Root Extract, with its rich history in traditional medicine, has emerged as a potent natural supplement for anti-aging.

Recent studies, including those by Zhang et al. (2022) and Shahrajabian (2019), have highlighted its remarkable benefits in delaying aging and improving overall vitality. [5]

Here’s what to expect when incorporating Astragalus Root Extract into an anti-aging regimen:

Enhanced Physical Abilities

  • Improved Mobility and Strength: Studies in Drosophila melanogaster, commonly known as fruit flies, have shown that Astragalus Root Extract improves climbing ability. This suggests potential benefits in enhancing mobility and physical strength in humans, especially as they age.
  • Regulated Food Intake: The extract has been observed to positively influence food intake patterns. This regulation can contribute to maintaining a healthy weight and metabolism, which are crucial in the aging process.

Delayed Aging Process

  • Antioxidant Mechanism: Astragalus Root Extract works through an antioxidant mechanism, reducing oxidative stress, a key factor in the aging process. This reduction can help in slowing down cellular aging and maintaining youthful vitality.
  • Prevention of Bone Loss: The extract has properties that prevent bone loss, a significant concern in aging individuals. This benefit is vital for maintaining bone health, reducing the risk of osteoporosis, and ensuring overall skeletal strength.

Skin Health Benefits

  • Improved Skin Elasticity and Texture: Astragalus Root Extract can enhance skin health, improving elasticity and texture. This leads to a more youthful appearance and a reduction in visible signs of aging like wrinkles and fine lines.
  • Enhanced Skin Hydration: The extract may contribute to better skin hydration, combating dryness and promoting a healthier, more vibrant skin complexion.
  • Protection Against Environmental Damage: Its antioxidant properties also protect the skin from environmental stressors, such as UV radiation and pollution, which can accelerate aging.

Overall Well-being

  • Boosted Immune Function: Astragalus Root Extract is known for its immune-boosting properties, which are essential for maintaining health and combating age-related illnesses.
  • Enhanced Energy Levels: Users can expect improved energy levels, contributing to an active lifestyle and better quality of life in later years.

Astragalus Root Extract’s Benefits in Boosting Exercise Performance and Combating Fatigue

Astragalus Root Extract has been identified as a significant natural supplement for enhancing exercise performance and providing anti-fatigue effects, especially in the context of exhaustive exercise.

Studies by Go et al. (2018) and Yeh et al. (2014) have demonstrated its efficacy as an ergogenic aid in training. [6]

Here’s what athletes, bodybuilders, and fitness enthusiasts can expect when incorporating Astragalus Root Extract into their sports nutrition regimen:

Enhanced Exercise Performance

  • Improved Endurance: Regular supplementation with Astragalus Root Extract can lead to enhanced endurance, allowing athletes and bodybuilders to train harder and for longer periods.
  • Increased Energy Levels: The extract contributes to higher energy levels, essential for intense training sessions and endurance sports.

Anti-Fatigue Effects

  • Reduced Perception of Fatigue: Astragalus Root Extract helps in reducing the perception of fatigue during and after workouts, enabling more efficient training and quicker recovery.
  • Enhanced Recovery Post-Exercise: The anti-fatigue properties aid in faster recovery post-exercise, reducing downtime and enhancing overall training effectiveness.

Ergogenic Aid in Training

  • Boost in Training Intensity: As an ergogenic aid, Astragalus Root Extract can help athletes and bodybuilders increase the intensity of their training sessions.
  • Support in High-Intensity Workouts: It is particularly beneficial for high-intensity interval training (HIIT) and other strenuous workout regimes, providing the necessary stamina and endurance.

Overall Training Benefits

  • Improved Athletic Performance: Consistent use can lead to overall improvements in athletic performance, including better strength, speed, and agility.
  • Support in Muscle Building: For bodybuilders, the extract’s benefits in enhancing exercise performance can contribute to more effective muscle building and sculpting.
  • Adaptation to Training Loads: The supplement aids in the body’s adaptation to increasing training loads, essential for progressive overload in strength training.

Holistic Health Benefits

  • Boosted Immune Function: Alongside exercise performance, Astragalus Root Extract supports immune function, crucial for maintaining health during intense training periods.
  • Balanced Energy Metabolism: It helps in balancing energy metabolism, which is vital for optimal performance and body composition.

Astragalus Root Extract’s Benefits on Immune Health: Harnessing Immunomodulatory and Antioxidant Powers for Health and Recovery

Astragalus membranaceus root, rich in polysaccharides, offers significant immunomodulatory and antioxidant properties, as highlighted in the study by Jin et al. (2014). [7]

These properties are particularly beneficial for individuals focused on anti-aging, bodybuilding, and sports nutrition. Here’s what to expect when incorporating Astragalus Root Extract into a health and fitness regimen:

Enhanced Immune Function

  • Strengthened Immune Response: The immunomodulatory properties of Astragalus Root Extract help in strengthening the body’s immune response, crucial for overall health and well-being.
  • Reduced Risk of Infections: Regular supplementation can lead to a reduced risk of infections, particularly important for athletes and bodybuilders who are often exposed to intense physical stress.

Powerful Antioxidant Effects

  • Combatting Oxidative Stress: The antioxidant properties of the extract play a key role in combatting oxidative stress, a common issue during intense physical activities and aging.
  • Protection Against Cellular Damage: These antioxidant effects provide protection against cellular damage, promoting longevity and reducing the signs of aging.

Support in Recovery and Performance

  • Enhanced Recovery Post-Exercise: The immunomodulatory and antioxidant properties aid in faster recovery post-exercise, reducing downtime and enhancing overall training effectiveness.
  • Improved Exercise Performance: By supporting the immune system and reducing oxidative stress, the extract can lead to improved exercise performance, essential for athletes and bodybuilders.

Benefits in Bodybuilding and Sports Nutrition

  • Support in Muscle Repair and Growth: The extract’s properties contribute to muscle repair and growth, crucial for bodybuilders aiming to increase muscle mass and strength.
  • Aid in Adaptation to Training Loads: It helps the body adapt to increasing training loads, essential for progressive overload in strength training.

Anti-Aging Advantages

  • Slowed Aging Process: The antioxidant effects contribute to slowing down the aging process, maintaining cellular health and vitality.
  • Enhanced Skin Health: These properties can also lead to improved skin health, combating signs of aging like wrinkles and fine lines.

Overall Health Benefits

  • Boosted Energy Levels: Regular use can lead to increased energy levels, contributing to an active lifestyle and better quality of life.
  • Balanced Immune System: The immunomodulatory effects ensure a balanced immune system, crucial for maintaining health and preventing age-related diseases.


Ron Males, a seasoned bodybuilder and sports performance enhancement specialist, is known for his unique perspective on the parallels between sports and sex. With a foundation in personal experience and comprehensive research on performance enhancement supplements, testosterone boosters, and muscle building supplements, Ron is dedicated to providing accurate information to counteract widespread misinformation. His interests extend to technology and biohacking, with a focus on optimizing all aspects of human life. Ron advocates for the use of herbs, performance-enhancing drugs, and other substances to boost performance in various settings, from corporate environments to physical fitness and daily life. He is always seeking innovative methods to expand human capabilities. As a supplement reviewer at, Ron uses his extensive knowledge to analyze supplements, providing readers with reliable, in-depth reviews to guide their decisions. His first-hand experience with several bodybuilding supplements, and understanding of herbs & bio-hacking makes him an invaluable asset to the community. Read more about him.