5). IGF-1 pathway


Endogenous (produced inside the body) HGH puts its actions into effect by “molecularly” joining straight to particular receptors on specific muscle tissues which includes muscles, connective tissue (tendons, ligaments, bone, and fat), as well as just about every major organ.


Growth hormone furthermore operates in a roundabout way by encouraging liver cells to produce and discharge polypeptide molecules referred to as somatomedins, of which, the most effective and extensively researched for its numerous health, anti aging and bodybuilding benefits is insulin-like growth factor-1 (IGF-1).

Like GH, IGF-1 has receptors through the entire body and assists in several capabilities.

The good news is, researchers are finding that the advantages of more youthful GH levels can also be made use of safely by naturally enhancing the body’s own hormone levels with the right nutrients and lifestyle practices.

One of those interesting natural ingredient , found in nature is Deer antler velvet” which is a natural combination of several amino acids and also contains IGF-1.

IGF-1 is primarily accountable for long bone growth in kids and it also has an effect on muscle mass growth and restoration of adults endocrine system.

In fact, IGF-1 is currently one of the most sought after natural compounds in the bodybuilding and athletic arena because of its immense benefits on muscle building, muscle recovery and preventing muscle loss or muscle degeneration (that comes naturally with aging).


IGF-1 significantly increases muscle mass by causing a condition of muscle hyperplasia (enhancement of quantity of freshly made new muscle cells) .

That’s why bodybuilders prefer it in a mass building steroid cycle when they need rapid increased muscle cell growth.

Some experts believe IGF supplementation is even better than HGH supplementation.

Why is that? It is because HGH causes IGF levels to rise in the liver first, then the muscle. While IGF-1 is more direct.

Getting the body’s energetic potential up, as well as using its ability to encourage the growth of satellite muscle cells and enabling them to mature into new muscle tissues it even supports the uptake and functions of many other ingredients in a HGH supplement.

More interestingly, it can result in the improved recovery of testicle size, if they have shrunk due to steroid abuse or other reasons like natural aging.

For bodybuilders, it prevents muscle loss and restores testicles size in PCT (post steroid cycle therapy).

H. Lee Sweeney, Ph.D., Professor and Chairman of Physiology at the University of Pennsylvaniais a well-known specialist on IGF-1 and the topic of the genetic enhancement of skeletal muscle in general.

lab rats

According to his statements on the muscle development, growth and rejuvenating attributes of IGF-1

Rats that were given IGF-1 and did nothing were bigger and stronger than rats that weren’t given IGF-1 but exercised.

And I’ll bet you guessed that rats that were given IGF-1 and exercised were the biggest, strongest rats in the house. The positive effects of IGF-1 on the rats continued for months after the rats stopped getting the supplemental hormone, whereas the exercising rats immediately lost size and strength as soon as they stopped exercising.

In a further research IGF-1 also seemed to prevent deterioration of muscle fibers in aged rats thereby confirming that it has a huge role to play in anti aging as well. Muscle loss and fat increase is one of the usually inevitable signs of aging.

The aging rats did not lose those muscles that are accountable for power and speed – and had the same speed and power output that they had when they were in their youthful years.

Scientific conclusions predict that when consumed by humans, it can increase “motor” ability of seniors (physical movement potential) like the capability to do more exercise.

Thus IGF-1 mechanism pathway , when combined with Dopaminergic and other pathways is one of the best strategy of anti aging, preventing muscle loss and to remain active during the later years and to naturally increase HGH in the body.

Deer antlers

When you consume deer antler velvet’s IGF-1 and also enhance HGH in the body by taking other ingredients, you are creating a perfect environment in the body to rejuvenate your “HGH-IGF-1” cycle or pathway.

Another compound having IGF-1 is Colostrum.

To quote Dr. Sweeney, “So we were able to conclude that IGF-1 could prevent all of the hallmarks of age-related atrophy and loss of skeletal muscle function in mammalian aging, at least based on the rodent model, and now we’re hoping to pursue this in larger animal models.”

For bodybuilders, a deer antler hGH supplement that includes this mechanism will help boost the potency of an anabolic cycle, this is as a consequence of a very unique quality of this supplement, that it will act on a number of different muscle tissues to reinforce growth.

Find out which body building product has Deer antler velvet and which anti aging product has it.

Such a HGH bodybuilding supplement will have the unique ability usually missed by other HGH products that is to encourage cell division, known as “mitogenesis”, and cell differentiation.

Which Means That In the case of IGF1 which does act on muscle tissue it will trigger the growth of fresh muscle fibers, and for bodybuilders consequently new receptors for testosterone.

Many bodybuilders have with one voice determined that IGF-1 enhances cycles of muscle building steroids considerably.

They also appear to be determined about its ability to decrease fat and enhance vascularity a good deal.

Another surprising effect for bodybuilders is that IGF-1 supplementation actually Reverses testicular atrophy.


Testicles if shrunken will come back to “full swing” as it were even in the middle of a steroid cycle.

There are a variety of lifestyle reasons that cause diminished GH and IGF-1 release. As an example, numerous reports say that central adiposity (the deposition of central body fat, around your belly region) causes huge GH decline.

Furthermore, it is well known that inadequate nutritional status, insufficient sleep, and not enough physical fitness can all bring about reduction in circulating GH and IGF-1, irrespective of age.

If you are looking for Deer antler velvet based HGH products, we recommend these two – Genf20 Plus and HyperGH 14X.

Ron Males, a seasoned bodybuilder and sports performance enhancement specialist, is known for his unique perspective on the parallels between sports and sex. With a foundation in personal experience and comprehensive research on performance enhancement supplements, testosterone boosters, and muscle building supplements, Ron is dedicated to providing accurate information to counteract widespread misinformation. His interests extend to technology and biohacking, with a focus on optimizing all aspects of human life. Ron advocates for the use of herbs, performance-enhancing drugs, and other substances to boost performance in various settings, from corporate environments to physical fitness and daily life. He is always seeking innovative methods to expand human capabilities. As a supplement reviewer at PowerandBulk.com, Ron uses his extensive knowledge to analyze supplements, providing readers with reliable, in-depth reviews to guide their decisions. His first-hand experience with several bodybuilding supplements, and understanding of herbs & bio-hacking makes him an invaluable asset to the PowerandBulk.com community. Read more about him.