• Ingredient Quality
  • Effectiveness
  • User Reviews
  • Price
  • Safety


Hi-Tech Pharmaceuticals Estrogenex 2nd Generation is a testosterone and anti-aromatase supplement designed for men looking to boost their testosterone levels, block excess estrogen, and achieve a lean, muscular physique. The product’s dual-action as both an estrogen and DHT blocker is appreciated among users, making it unique among the various estrogen blockers in the market, (especially given DHT’s association with hair thinning). With a blend of potent ingredients, it aims to restore healthy testosterone levels, improve performance, and maintain lean muscle mass. While many users have reported positive results, some have mentioned a strong odor associated with the product and varied results. While certain ingredients are backed by science, others, like the phytoestrogen Coumesterol, seem out of place. The product’s potential is further clouded by issues like Chrysin‘s questionable bioavailability in humans and the fact that it uses a proprietary blend. Overall, while promising, the product’s formulation could benefit from a more targeted, transparent and research-driven approach.


  1. Testosterone Boosting: Estrogenex is designed to help men increase their testosterone levels, which is essential for muscle growth.
  2. Anti-Aromatase: The product helps in blocking the excess levels of estrogen that can cause issues like gynecomastia and lethargy.
  3. Comprehensive Ingredient List: Contains a blend of ingredients like 6-bromoandrostenedione, chrysin, indole-3-carbinol (IC3), coumestrol, eurycoma longifolia, muira-puama, and quercetin which have various health benefits.
  4. Positive User Reviews: Many users have reported increased energy, stamina, improved mood, libido, and muscle strength.
  5. Affordable Price: The product is priced at $49.95 but is often on sale for $27.95.


  1. Odor: Some users have reported that the product has a strong odor.
  2. Uses a proprietary blend: Exact quantities of ingredients can’t be known
  3. Phytoestrogen Coumesterol, that acts as estrogen seems out of place in this formula.
  4. Chrysin has questionable bioavailability in humans
  5. Varied Results: While some users noticed significant benefits, others reported minimal changes.
  6. Requires Patience: The product might take some time to show noticeable results.

Introduction to Hi-Tech Pharmaceuticals Estrogenex 2nd Generation

Are you looking for a product to help you restore your natural testosterone levels, build muscle and reduce the signs of aging?

The company Hi-Tech Pharmaceuticals claims their product Estrogenex 2nd Generation is be the perfect solution for you!

Estrogenex is a 2nd generation testosterone and anti-aromatase supplement from Hi-Tech Pharmaceuticals. It is designed to help men increase their testosterone levels while balancing the production of Estradiol and DHT, which is essential for muscle growth. Additionally, Estrogenex helps block excess levels of estrogen that cause gynecomastia and lethargy.

If you’re looking to regain your energy and maintain a lean, muscular physique, then Estrogenex could be the product you’ve been searching for.

How Estrogenex 2nd generation performs? (Scale of 1 to 5):

  1. Ingredient Quality: 4 – Given the comprehensive list of ingredients and their known benefits.
  2. Effectiveness: 4 – Based on the majority of positive user reviews.
  3. User Reviews: 4 – Most users have reported positive results, with a few exceptions.
  4. Price: 4 – Reasonably priced, especially when on sale.
  5. Safety: 4 – No major side effects reported, but as with any supplement, it’s essential to consult with a healthcare professional.

Our Take on Estrogenex 2nd generation

Estrogenex 2nd Generation presents a comprehensive blend of ingredients, showcasing Hi-Tech Pharmaceuticals’ attempt to create a dual-action testosterone booster and estrogen modulator. However, while some ingredients have a solid foundation in science, others seem to be added without a clear rationale, especially in the context of estrogen modulation.

For instance, the inclusion of Coumesterol, a phytoestrogen, raises eyebrows. Additionally, while Chrysin‘s in-vitro potential is recognized, its real-world application in humans remains dubious due to bioavailability issues.

In essence, while Estrogenex 2nd Generation has the potential to be a powerhouse, it falls short in certain areas. A more focused approach, targeting well-researched ingredients with clear dosages and synergistic effects, would elevate this product to the next level. As it stands, it’s a mixed bag with both hits and misses.

Ingredients Analysis:

  1. 5a-androstan-3b-ol-17-one: This prohormone is known for its potential to increase testosterone levels. While it may boost testosterone, its conversion rate and the subsequent effects on estrogen modulation are areas of ongoing research, suggesting room for exploration.
  2. Chrysin 99%: Chrysin has been touted as an aromatase inhibitor, which means it could prevent the conversion of testosterone to estrogen. However, studies have shown that while it may be effective in a petri dish, its bioavailability in the human body is questionable.
  3. Indole-3-Carbinol: Found in cruciferous vegetables, it’s believed to modulate estrogen metabolism. While it has potential benefits, the dosage and its direct impact on testosterone levels are not clear-cut.
  4. Eurycoma Longifolia 150:1 Extract: Often referred to as Tongkat Ali, this herb is known for its testosterone-boosting properties. The 150:1 extract indicates a concentrated form. Numerous studies have underscored its efficacy in elevating testosterone levels, making it a sought-after ingredient in many male enhancement supplements. Its natural origin, combined with its proven effectiveness, positions Eurycoma Longifolia 150:1 Extract as a premier choice for those seeking a natural boost in their testosterone levels.
  5. Muira Puama 20:1 Extract: Traditionally used as an aphrodisiac, Muira Puama, is often termed as the “Viagra of the Amazon”. It is a renowned herb celebrated for its vitality-enhancing properties. The 20:1 extract indicates a robust concentration, ensuring users receive the full spectrum of its benefits. Historically used as an aphrodisiac, modern research is increasingly validating its potential in supporting healthy testosterone levels and enhancing libido. With its natural potency and a legacy rooted in traditional medicine, Muira Puama 20:1 Extract stands out as a top-tier choice for individuals aiming to naturally invigorate their energy and vigor.
  6. Quercetin: A flavonoid with antioxidant properties. While it has numerous health benefits, its role as a testosterone booster or estrogen modulator is not well-established.
  7. Coumesterol 40%: A phytoestrogen that might act similarly to estrogen in the body. Its inclusion in a product designed to block estrogen seems counterintuitive.
  8. 6, 7 Dihydroxybergamottin & Naringen: Both are known to enhance the absorption of other compounds. While they might improve the bioavailability of other ingredients, their direct role in testosterone boosting or estrogen modulation is negligible.

Clinical Studies on Hi-Tech Pharmaceuticals Estrogenex Ingredients

This proprietary blend with Extend-Rx Technology contains 5a-androstan-3b-ol-17-one, Chrysin 99%, Indole-3-Carbinol, Eurycoma Longifolia 150:1 Extract (standardized to 30% Glyco-Proteins), Muira Puama 20:1 Extract (Root), Quercitin, Coumesterol 40% (Flavonoid), 6, 7 Dihydroxybergamottin (Fruit), and Naringen (Fruit).

This blend may help improve body composition and muscular strength, support physical performance and inflammation, lower estrogen levels, increase testosterone levels, improve related symptoms in men with low testosterone levels, support healthy sex drives for both men and women, improve exercise performance and reduce inflammation, blood pressure, and blood sugar levels, maintain estrogen levels, produce natural testosterone, and support intestine health, as well as provide antioxidant, anti-carcinogenic, and cholesterol lowering activity.

    • 6-bromoandrostenedione
    • This article from NCBI discusses the effects of 6-bromoandrostenedione on testosterone levels in animals. The study found that 6-bromoandrostenedione increased testosterone levels in rats but further research is needed to determine its effects in humans.
    • Chrysin
    • This article from NCBI looks at the effects of chrysin on testosterone levels in animals and humans. The study found that while chrysin was effective in increasing testosterone levels in animals, no significant changes were observed in human subjects.
    • Indole-3-Carbinol (IC3)
    • This article from NCBI examines the effects of indole-3-carbinol on hormones and prostate health. The study found that IC3 has the potential to modulate hormones in the body and may have beneficial effects on prostate health.

Here is more research & information on testosterone-boosting effects and health benefits for men on the secondary ingredients:

What Does Estrogenex 2nd Generation Do?

Estrogenex 2nd Generation from Hi-Tech Pharmaceuticals is an advanced testosterone and anti-aromatase supplement designed to help aging men maintain healthy sex hormone levels. This formula contains 6-bromoandrostenedione, chrysin, indole-3-carbinol (IC3), coumestrol, eurycoma longifolia, muira-puama, and quercetin, which work together to free up testosterone, block excess estrogen, and maintain optimal levels of endogenous anabolic hormones.

By using Estrogenex 2nd Generation, users can restore healthy testosterone levels, improve performance, and maintain lean muscle mass, all while reducing the effects of aging. Order yours online today to start experiencing the benefits of this advanced supplement.


What do people say about Estrogenex 2nd generation?

Users have generally expressed positive feedback regarding Estrogenex, highlighting its effectiveness in improving mood, libido, and aiding fat loss. Many consider it a top-quality estrogen blocker, though some mention a strong odor associated with the product.

Particularly notable is its impact on energy, stamina, and muscle density, with one 42-year-old user observing significant changes in just two weeks. The product’s dual-action as both an estrogen and DHT blocker is appreciated, especially given DHT’s association with hair thinning.

While some users advise patience to witness its full effects, others have experienced boosts in strength and muscle power. However, a few users suggest that the benefits might vary based on individual testosterone levels.

Estrogenex user reviews

1). I used Estrogenex over the course of a month after a light SARM cycle. It definitely improved my mood and libido, and helped me lose some fat along with a decent diet.

2). Estrogenex is definitely one of the highest quality E blockers I’ve taken, but it has a strong odor. It’s not a big issue, but it’s worth noting to wash your hands after handling it, as the smell will linger if you touch it.

3). I rarely write reviews, but this product has excited me so much that I had to share my honest opinion. I’m a 42-year-old man and it has given me so much energy and stamina. My strength has increased, my body fat is lower than it was in my 20s, my muscles look and feel hard and dense, and my recovery times are amazing. I’m on my second bottle and just ordered more, and I saw and felt a difference two weeks into my first bottle. I highly recommend this product.

4). In my opinion, Estrogenex is the best estrogen blocker on the market. I’ve used many estrogen blockers, but this one also contains DHT blockers, which is important because DHT can cause hair thinning. Many stacks will increase DHT, but not with this product. That’s why I think it’s the best blocker for both DHT and estrogen. Say no to gynecomastia.

5). Products like Estrogenex take time to work, so be patient. So far, I haven’t seen any amazing results, but I’ve only been using it for 10 days. My libido is up and I have a slight sense of well-being, and I’m currently using it as a test booster and estrogen blocker, stacked with Test HD. I think it’s definitely worth trying for PCT and overall hormone balance, and I haven’t experienced any bad side effects.

6). I think Estrogenex is a great product! I’ve noticed a significant boost in strength and muscle power, and I can do more reps with more weight. That’s about it, though. I haven’t noticed any other benefits like an increase in mood or sex drive. I’m currently only using 2 pills a day instead of 3, and it could be working well for me because I have extremely low testosterone, but I’m not sure.

Ron Males, a seasoned bodybuilder and sports performance enhancement specialist, is known for his unique perspective on the parallels between sports and sex. With a foundation in personal experience and comprehensive research on performance enhancement supplements, testosterone boosters, and muscle building supplements, Ron is dedicated to providing accurate information to counteract widespread misinformation. His interests extend to technology and biohacking, with a focus on optimizing all aspects of human life. Ron advocates for the use of herbs, performance-enhancing drugs, and other substances to boost performance in various settings, from corporate environments to physical fitness and daily life. He is always seeking innovative methods to expand human capabilities. As a supplement reviewer at PowerandBulk.com, Ron uses his extensive knowledge to analyze supplements, providing readers with reliable, in-depth reviews to guide their decisions. His first-hand experience with several bodybuilding supplements, and understanding of herbs & bio-hacking makes him an invaluable asset to the PowerandBulk.com community. Read more about him.

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Dr. Aleksandar Grbovic is a highly experienced medical doctor specializing in cardiovascular and diabetes medications, with a notable academic tenure at the University of Belgrade's Faculty of Medicine. He has a significant association with the Institute of Occupational Medicine "Serbian Railways," a primary care facility serving over 100,000 patients across Serbia. His medical expertise extends to Radiology, and he has contributed to the development of educational materials for US medical board exams. Dr. Grbovic is also a freelance medical writer, aiming to bridge the communication gap between doctors and patients by simplifying complex medical topics. As a Senior Medical Reviewer at PowerandBulk.com, he uses his extensive knowledge to provide accurate and understandable health information to the public. Read more about him.