Choline supplements, particularly CDP-choline, are gaining attention not just for their cognitive benefits but also for their potential impact on growth hormone (GH) levels. CDP-choline, also known as citicoline, stands out in the world of supplements for its unique properties and health benefits.

But what really piques interest is its possible relationship with GH, a hormone crucial for growth, cell repair, and overall health. This article delves into the intriguing connection between CDP-choline and GH, exploring whether this supplement could be a key to enhancing GH levels.

Understanding CDP-Choline

CDP-choline, or citicoline, is more than just a dietary supplement; it’s a compound that plays a vital role in the functioning of your brain.

It’s composed of choline and cytidine and, once ingested, is broken down into these components before being reformed in the brain. This process aids in the synthesis of phosphatidylcholine, a fundamental component of brain cell membranes.

Choline supplements, in general, are celebrated for their role in cognitive function and overall brain health. They contribute to the production of acetylcholine, a neurotransmitter essential for memory and learning. [1]

But CDP-choline goes a step further. It not only supports brain health but also aids in neuroprotection and repair, making it a standout choice for cognitive enhancement. [2]

What sets CDP-choline apart from other choline supplements is its two-component structure. While other choline supplements focus solely on increasing choline levels, CDP-choline also provides cytidine, which is converted into uridine in the body.

Uridine is crucial for synaptic function and plasticity, adding another layer to CDP-choline’s cognitive benefits. This dual action makes CDP-choline a unique and powerful supplement in the realm of brain health.

The Link Between Choline and Growth Hormone

The connection between choline and growth hormone (GH) is a fascinating area of study, especially for those interested in bodybuilding, anti-aging, and overall wellness. Choline, a key nutrient, plays a crucial role in various bodily functions, including brain health and metabolism. But its potential impact on GH, a hormone vital for growth, cell repair, and metabolism, is what truly captures attention.

A study published on PubMed [3] sheds light on this intriguing relationship. It explored the effects of CDP-choline, a specific form of choline, on GH levels.

The study found that after administering CDP-choline, there was a significant increase in GH levels in the subjects. For those seeking natural ways to boost GH, whether for muscle building, anti-aging, or general health, this finding is particularly compelling.

So, how does CDP-choline influence GH secretion? It’s believed that CDP-choline may play a role in the brain’s regulation of GH release. GH is produced in the pituitary gland, but its release is controlled by signals from the brain.

Choline is crucial for brain function and neurotransmitter production, which could mean that adequate levels of choline, especially in the form of CDP-choline, might help optimize the brain’s ability to signal GH release.

For bodybuilders, higher GH levels mean better muscle growth and recovery. In the context of anti-aging, increased GH can lead to improved skin elasticity, bone density, and overall vitality.

This study suggests that CDP-choline could be a valuable addition to the regimen of those looking to harness these benefits of GH. However, it’s important to remember that supplements should complement a healthy lifestyle and not replace other essential health practices.

More Scientific Evidence on CDP-Choline and Growth Hormone

The quest for natural ways to boost growth hormone (GH), especially among those interested in bodybuilding and anti-aging, leads us to another fascinating study [4] on CDP-choline.

This study delves deeper into how this particular choline supplement might affect GH levels, offering valuable insights for anyone considering HGH supplements.

In this study, researchers explored the impact of CDP-choline on GH secretion. They found that administering CDP-choline could potentially increase GH levels. This is big news for those looking to enhance muscle growth, recovery, or seeking the anti-aging benefits of GH.

Increased GH levels can mean improved muscle mass, better skin elasticity, and overall rejuvenation, which are key goals for many in the fitness and wellness communities.

The findings of this study are crucial in understanding the relationship between CDP-choline and GH. They suggest that CDP-choline could be more than just a brain health supplement; it might also be a natural catalyst for boosting GH levels.

This is particularly significant when compared to other studies on GH enhancement, which often focus on more direct methods like hormone injections. CDP-choline offers a more natural, less invasive approach.

However, it’s important to approach these findings with a balanced perspective. While the study shows promise, supplements like CDP-choline should be part of a broader health and wellness strategy, including a balanced diet, regular exercise, and adequate sleep.

For those considering HGH supplements for bodybuilding or anti-aging, CDP-choline might be a beneficial addition, but it’s not a magic pill. It’s one piece of the puzzle in achieving optimal health and wellness.

Comprehensive Research on Cholinergic supplements in boosting HGH levels

Cholinergic supplements enhance human growth hormone (HGH) levels primarily through their inhibitory effects on somatostatin (growth hormone-inhibiting hormone, that suppresses HGH release from pituitary) secretion.

Here’s an overview based on various clinical studies:-

Cholinergic Agonist Drugs and GHRH-Induced GH Release

Cholinergic agonist drugs play a significant role in enhancing growth hormone (GH) levels, particularly in relation to growth hormone-releasing hormone (GHRH). A study by Moreno Esteban et al. (1993) delved into this relationship, revealing that these drugs can potentiate the GH release induced by GHRH. [6]

This is primarily achieved by inhibiting the secretion of somatostatin, a hormone that normally suppresses GH release.

For individuals interested in boosting their GH levels for bodybuilding or anti-aging purposes, understanding the impact of cholinergic agonists could be key. These drugs might offer a way to enhance the natural GH release in response to GHRH, potentially leading to improved muscle growth and rejuvenation.

Cholinergic Supplements like Pyridostigmine, Neostigmine, and Physostigmine

Moving beyond prescription drugs, certain cholinergic supplements like Pyridostigmine, Neostigmine, and Physostigmine have shown promise in increasing GH secretion. According to research by Mazza et al. (1994), these supplements work by inhibiting the release of endogenous somatostatin. [7]

This inhibition is crucial because somatostatin is known to suppress GH release. By reducing somatostatin levels, these supplements can indirectly boost GH secretion. This finding is particularly relevant for those seeking natural supplements to enhance GH levels for improved muscle mass, better recovery after workouts, or anti-aging effects.

Cholinergic Augmentation in Older Diabetic Rats

A study by Ismail et al. (1995) provides further insights, especially in the context of aging and health conditions like diabetes. This research found that cholinergic augmentation with pyridostigmine could reverse the blunted GH responses to GHRH in older diabetic rats. [8]

The study suggests that this effect might be due to reduced hypothalamic cholinergic signaling to the somatostatinergic neuron. For older individuals or those with health conditions that affect GH levels, such as diabetes, understanding the potential of cholinergic augmentation could be crucial.

It indicates a possible pathway to enhance GH levels, which can be particularly beneficial in combating age-related decline in GH and managing health conditions that affect hormonal balance.

Anecdotal Evidence and User Experiences

When it comes to understanding the effects of supplements like CDP-choline on growth hormone (GH) levels, anecdotal evidence can be as enlightening as scientific studies. On forums like Reddit and Longecity, users often share their personal experiences with various supplements, providing a real-world glimpse into their potential effects.

For those considering HGH supplements for bodybuilding, anti-aging, or general health, these user reports can offer valuable insights.

Many users on such forums report positive effects of CDP-choline on their overall well-being, with some specifically noting perceived improvements in areas typically associated with increased GH levels, such as better muscle recovery, enhanced focus, and even improved skin quality.

There was one particular study titled- “Effects of cytidine 5′-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects” which aligns with these anecdotal evidence. [5]

While these experiences are subjective, they provide a human aspect to the discussion about CDP-choline’s potential benefits.

However, it’s important to note that anecdotal evidence can vary widely and may not always align with scientific findings. While some users report noticeable benefits, others may not experience any significant changes. This discrepancy highlights the individual nature of supplement use and the fact that what works for one person may not work for another.

While studies suggest a potential link between CDP-choline and increased GH levels, user experiences offer a more nuanced view, showing a range of responses.

This variance underscores the importance of considering both scientific research and personal experiences when evaluating the potential benefits of supplements like CDP-choline.

For those exploring HGH supplements, it’s a reminder that personal experimentation, under the guidance of a healthcare professional, is often a key part of finding what works best for their specific goals and needs.

Benefits & Risks of using Choline for HGH

Potential Benefits of CDP-Choline Supplementation

  • Enhances Muscle Growth and Recovery: Beneficial for bodybuilders and fitness enthusiasts due to GH’s role in muscle development.
  • Anti-Aging Effects: GH’s involvement in anti-aging processes may improve skin health and overall vitality.
  • Cognitive Enhancements: Impact on brain health, coupled with increased GH, could lead to improved memory, focus, and cognitive function.

Potential Risks and Side Effects of CDP-Choline Supplementation

  • Mild Side Effects: Some individuals might experience headaches, insomnia, or digestive disturbances.
  • Individual Variability: Responses to supplements can vary; what is safe and effective for one might not be the same for another.

Recommendations for Safe and Effective Use

  • Start with Lower Doses: Begin with a small dose to assess tolerance, then gradually increase as needed.
  • Consult Healthcare Professionals: Especially important for those with pre-existing health conditions or on other medications.
  • Choose Reputable Sources: Ensure quality and purity by purchasing from trusted brands in the supplement industry.

CDP-choline vs Alpha GPC for HGH release- Comparison of two choline supplements Which is more efficient?

Lets compare the 2 most popular choline supplements in their role as HGH supplements. Several clinical studies done on both these compounds can help guide us, and conclude which supplement might be better in what cases.

All-in-all, both CDP-choline and Alpha GPC offer unique benefits that may influence HGH release, with CDP-choline showing more direct involvement in hormonal stimulation. However, Alpha GPC’s contribution to overall brain health and neurovascular function & benefits in workouts & performance enhancement should not be overlooked, as these factors can indirectly support hormonal balance and HGH secretion.

Evaluating and comparing CDP-choline and Alpha GPC as HGH supplements in various categories requires a nuanced understanding of their mechanisms and effects based on clinical studies. Here’s a comparative analysis on a scale of 1 to 10, with 10 being the most effective:

Anti-Aging Benefits

  • CDP-Choline: 7/10. Its role in enhancing HGH release can contribute to anti-aging effects like improved skin health and vitality.
  • Alpha GPC: 8/10. Besides HGH release, its neuroprotective properties may offer broader anti-aging benefits, including cognitive health.

Fitness, Athletic and Muscle-building Benefits

  • CDP-Choline: 8/10. Its direct stimulation of HGH release is crucial for muscle growth and recovery, making it highly beneficial for fitness enthusiasts.
  • Alpha GPC: 8/10. While it supports overall vitality, some clinical studies also suggest its role in boosting strength and muscle-building. [9]

Energy and Vitality Benefits

  • CDP-Choline: 7/10. Enhances overall hormonal balance, contributing to energy levels.
  • Alpha GPC: 8/10. Known for improving cognitive function, which can indirectly boost energy and vitality.

Cognitive Function/Brain Health Improvement

  • CDP-Choline: 8/10. Directly influences neurotransmitter production, enhancing cognitive functions.
  • Alpha GPC: 9/10. Strongly associated with cognitive improvements and neuronal health.

Libido and Sexual Health Benefits

  • CDP-Choline: 6/10. While it may enhance hormonal balance, direct effects on libido are less clear.
  • Alpha GPC: 6/10. Similar to CDP-choline, its impact on sexual health is indirect and less pronounced.

Sleep Quality Optimization & Stress Control

  • CDP-Choline: 7/10. Can improve sleep quality through hormonal regulation.
  • Alpha GPC: 7/10. Its cognitive benefits might contribute to better stress management and sleep quality.

Health and Longevity

  • CDP-Choline: 8/10. Its role in hormonal balance and cognitive function supports overall health and longevity.
  • Alpha GPC: 8/10. Offers comprehensive benefits for brain health, which is crucial for long-term well-being.

Weight Management Benefits

  • CDP-Choline: 7/10. HGH release can aid in fat metabolism, contributing to weight management.
  • Alpha GPC: 6/10. While beneficial, its impact on weight management is more indirect compared to CDP-choline.

Recovery and Rehabilitation

  • CDP-Choline: 8/10. Directly enhances HGH release, aiding in muscle recovery and rehabilitation.
  • Alpha GPC: 7/10. Supports overall vitality, which can aid in recovery processes, though less directly than CDP-choline.

Comparison of clinical studies : CDP-choline and Alpha-GPC

CDP-Choline (Citicoline)

Stimulation of Hormone Release

CDP-choline has been found to play a significant role in stimulating hormone release, including Human Growth Hormone (HGH). A study by Çavun and Savci (2004) revealed that CDP-choline can increase plasma ACTH and potentiate the stimulated release of GH, TSH, and LH.

This indicates that CDP-choline enhances HGH release through the cholinergic system, making it a potential supplement for those interested in boosting their HGH levels for benefits like muscle growth, anti-aging, and overall hormonal balance (Çavun & Savci, 2004).

Impact on Neurotransmissions

Further studies, such as those by Cansev et al. (2008), demonstrate that CDP-choline increases plasma glucagon concentrations by enhancing peripheral nicotinic and muscarinic cholinergic neurotransmissions.

This increase in neurotransmitter activity may indirectly influence HGH release. For individuals seeking natural ways to enhance HGH for health and fitness goals, understanding the role of CDP-choline in neurotransmitter modulation can be crucial (Cansev et al., 2008).

Alpha GPC (L-Alpha glycerylphosphorylcholine)

Modulation of Neurovascular Unit Physiology

Alpha GPC contributes significantly to the modulation of neurovascular unit cells’ physiology. A review by Roy et al. (2022) highlighted its neuroprotective effects, which are essential for overall brain health.

While this doesn’t directly link to HGH release, the improved neurovascular function could create a conducive environment for hormonal balance, potentially benefiting HGH secretion. This aspect is particularly appealing to those interested in both cognitive health and hormonal regulation (Roy et al., 2022).

Cognitive Function and Neuronal Health

Alpha GPC is renowned for its role in enhancing cognitive function and supporting neuronal health, as indicated in research by Lee et al. (2017). While this study doesn’t establish a direct correlation with HGH release, it suggests a broader range of neurological benefits.

For individuals prioritizing brain health alongside physical fitness, Alpha GPC’s dual action on cognitive function and potential influence on HGH release makes it an attractive supplement choice (Lee et al., 2017).


Ron Males, a seasoned bodybuilder and sports performance enhancement specialist, is known for his unique perspective on the parallels between sports and sex. With a foundation in personal experience and comprehensive research on performance enhancement supplements, testosterone boosters, and muscle building supplements, Ron is dedicated to providing accurate information to counteract widespread misinformation. His interests extend to technology and biohacking, with a focus on optimizing all aspects of human life. Ron advocates for the use of herbs, performance-enhancing drugs, and other substances to boost performance in various settings, from corporate environments to physical fitness and daily life. He is always seeking innovative methods to expand human capabilities. As a supplement reviewer at, Ron uses his extensive knowledge to analyze supplements, providing readers with reliable, in-depth reviews to guide their decisions. His first-hand experience with several bodybuilding supplements, and understanding of herbs & bio-hacking makes him an invaluable asset to the community. Read more about him.

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Dr. Aleksandar Grbovic is a highly experienced medical doctor specializing in cardiovascular and diabetes medications, with a notable academic tenure at the University of Belgrade's Faculty of Medicine. He has a significant association with the Institute of Occupational Medicine "Serbian Railways," a primary care facility serving over 100,000 patients across Serbia. His medical expertise extends to Radiology, and he has contributed to the development of educational materials for US medical board exams. Dr. Grbovic is also a freelance medical writer, aiming to bridge the communication gap between doctors and patients by simplifying complex medical topics. As a Senior Medical Reviewer at, he uses his extensive knowledge to provide accurate and understandable health information to the public. Read more about him.